Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
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چکیده
منابع مشابه
The ErbB/HER family of protein-tyrosine kinases and cancer.
The human epidermal growth factor receptor (EGFR) family consists of four members that belong to the ErbB lineage of proteins (ErbB1-4). These receptors consist of a glycosylated extracellular domain, a single hydrophobic transmembrane segment, and an intracellular portion with a juxtamembrane segment, a protein kinase domain, and a carboxyterminal tail. Seven ligands bind to EGFR including epi...
متن کاملThe ErbB/HER receptor protein-tyrosine kinases and cancer.
The ErbB/HER protein-tyrosine kinases, which include the epidermal growth factor receptor, consist of a growth-factor-binding ectodomain, a single transmembrane segment, an intracellular protein-tyrosine kinase catalytic domain, and a tyrosine-containing cytoplasmic tail. The genes for the four members of this family, ErbB1-ErbB4, are found on different human chromosomes. Null mutations of any ...
متن کاملErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer.
Breast cancer is one of the most common cancers in humans. However, our understanding of the cellular and molecular mechanisms underlying tumorigenesis in breast tissues is limited. Here, we identified a molecular mechanism that controls the ability of breast cancer cells to form multicellular spheroids (mammospheres). We found that heregulin (HRG), a ligand for ErbB3, induced mammosphere forma...
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Tight control of cell proliferation and morphogenesis in conjunction with programmed cell death (apoptosis) is required to ensure normal tissue patterning. Alterations that cause an imbalance of the cellular signals that control these events may promote cell growth, suppress apoptosis, and enhance cell invasion, resulting in oncogenesis. Many of these signals are regulated by receptor tyrosine ...
متن کاملErbB2 Is Necessary for Induction of Carcinoma Cell Invasion by Erbb Family Receptor Tyrosine Kinases
The epidermal growth factor (EGF) family of tyrosine kinase receptors (ErbB1, -2, -3, and -4) and their ligands are involved in cell differentiation, proliferation, migration, and carcinogenesis. However, it has proven difficult to link a given ErbB receptor to a specific biological process since most cells express multiple ErbB members that heterodimerize, leading to receptor cross-activation....
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2000
ISSN: 1465-542X
DOI: 10.1186/bcr51